Section 4.2 Posology and method of administration
Adults (including the elderly) and children:
Creon 40000 should only be used if the patient requires equal to or more than 40,000 lipase units per meal or snack.
Initially one or two capsules with meals. The capsules should be swallowed whole, without crushing or chewing, with enough fluid during or after each meal or snack. Dose adjustments, if required, should be done slowly, with careful monitoring of response and symptomatology.