When a pharmaceutical company changes an SPC or PIL, a new version is published on medicines.ie. For each version, we show the dates it was published on medicines.ie and the reasons for change.
old wording new wording Children under 40Kg# Glomerular filtration rate Oral treatment < 30 No adjustment necessary 10-30 ml/min 15mg/kg given twice daily < 10ml / min 15mg/kg given as as single daily dose Children under 40Kg# Glomerular filtration rate Oral treatment < 30 No adjustment necessary 10-30 ml/min 15mg/kg given twice daily (maximum 500mg/twice daily) < 10ml / min 15mg/kg given as as single daily dose (maximum 500mg)
old wording
new wording
Children under 40Kg#
Glomerular filtration rate
Oral treatment
< 30
No adjustment necessary
10-30 ml/min
15mg/kg given twice daily
< 10ml / min
15mg/kg given as as single daily dose
(maximum 500mg/twice daily)
15mg/kg given as as single daily dose (maximum 500mg)
4.5 Interaction with other medicinal products and other forms of interaction
Probenecid decreases the renal tubular excretion of amoxicillin. Concurrent use with amoxicillin may result in increased and prolonged blood levels of amoxicillin.
Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.
In common with other antibiotics, amoxicillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives
4.8: Undesirable effects
Infections and Infestations
Very rare:Mucocutaneous candidiasis
Gastrointestinal disorders
#Common: Diarrhoea and nausea.
#Uncommon: Vomiting.
Very rare:
Black hairy tongue
Dry Powder:Do not Store above 25C. Keep bottle tightly closed in order to protect from moisture
Reconstituted Suspension:
Do not store above 25C