|Side-effects: Unwanted effects occur mainly at the start of treatment, if the dosage is raised too rapidly, if large doses are employed, or in elderly patients. They are often transitory and can be attenuated or eliminated by reducing the dosage; they are seldom severe enough to necessitate withdrawal of the medication. Should nausea persist following a reduction in dosage, it is recommended that Lioresal be ingested with food or a milk beverage. Lowering of the convulsion threshold and convulsions may occur, particularly in epileptic patientsCertain patients have shown increased muscle spasticity as a paradoxical reaction to the medicationIn patients with a case history of psychiatric illness or with cerebrovascular disorders (e.g. stroke) as well as in elderly patients, adverse reactions may assume a more serious form.Adverse reactions are ranked under heading of frequency, the most frequent first, using the following convention: very common (≥ 1/10); common (≥ 1/100, < 1/10); uncommon (≥ 1/1,000, < 1/100); rare (≥ 1/10,000, < 1/1,000) very rare (< 1/10,000), including isolated reports|
Certain patients have shown increased spasticity as a paradoxical reaction to the medication. An undesirable degree of muscular hypotonia - making it more difficult for patients to walk or fend for themselves - may occur and can usually be relieved by re-adjusting the dosage (i.e. by reducing the doses given during the day and possibly increasing the evening dose).
|Nervous System Disorders: |
Respiratory depression, light-headedness, lassitude, exhaustion, mental, confusion, dizziness, headache, insomnia, euphoria mood, depression, muscular weakness, ataxia, tremor, hallucinations, nightmares, myalgia, nystagmus, dry mouth.
Paraesthesia, dysarthria dysgeusia. Lowering of the convulsion threshold and convulsions may occur, particularly in epileptic patients.
Accommodation disorders, visual disturbance.
|Gastro-intestinal disorders: |
Mild gastro-intestinal disturbances constipation, diarrhoea, retching and vomiting.
|Cardiac disorders |
Diminished cardiovascular function.
|Renal and urinary disorders: |
Pollakiuria, enuresis, dysuria.
|Reproductive system and breast disorders:|
|Hepatobiliary disorders: |
Hepatic function abnormal.
|Skin and subcutaneous tissue disorders: |
Hyperhidrosis, skin rash.