Leukeran 2mg Film-coated Tablets
1. What Leukeran is and what it is used for
2. What you need to know before you take Leukeran
3. How to take Leukeran
4. Possible side effects
5. How to store Leukeran
6. Contents of the pack and other information
Leukeran contains an active substance called chlorambucil which belongs to a group of medicines called cytotoxics (also called chemotherapy). This medicine is used to treat certain type of cancers affecting human blood and lymphatic system. Your doctor will be able to explain how Leukeran might help in your particular condition.
Leukeran is used in patients with:
You are allergic to chlorambucil or any of the other ingredients of this medicine (listed in section 6).
Leukeran should not be used for the treatment of non-malignant cancer.
If you are not sure, talk to your doctor before taking Leukeran.
Talk to your doctor or nurse before you take this medicine if:
It is possible that the use of Leukeran, particularly long term use, may increase the risk of developing a secondary blood cancer called acute secondary haematological malignancy. In many cases, patients who develop this have also received another type of chemotherapy or some form of radiation therapy. Symptoms of a secondary blood cancer include tiredness, fever, infection and bruising. Tell your doctor as soon as possible if you have any of these symptoms (see section 4).
Please tell your doctor if you are taking or have recently taken any of the following:
Please tell your doctor if you are taking or have recently taken or may take any other medicines, including medicines obtained without a prescription. This includes herbal medicines also.
Leukeran should be taken on an empty stomach. See section 3.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, it is important to tell your doctor this before you are given Leukeran.
You should not take Leukeran if you are planning to have a baby. This applies to both men and women. Treatment with Leukeran is not recommended during pregnancy because it can be very damaging to your unborn baby.
You should not breast-feed while taking Leukeran.
Leukeran can affect ovaries or sperm, which may cause infertility (inability to have a baby). In women menstruation can stop (amenorrhoea) and in men, a complete lack of sperm can be observed (azoospermia). Use a reliable form of contraception to avoid pregnancy if either you or your partner is taking Leukeran. Ask your doctor for advice.
No information on the effects of Chlorambucil on the ability to drive and use machines is available.
Leukeran tablets contain lactose, a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before you take this medicine.
Always take Leukeran exactly as your doctor has told you. Check with your doctor if you are not sure.
Leukeran should only be given to you by a specialist doctor who is experienced in treating cancer.
Your doctor will advise you of how much and how often you will need to take this medicine. Your dosage is calculated based on your body weight and your disease.
The dose of Leukeran depends on the type of your disease condition (see section 1).
Chronic Lymphocytic Leukaemia
Tell your doctor immediately or go to a hospital straight away. Ensure to take the medicine pack with you, even if there are no tablets left.
Tell your doctor. Do not take a double dose to make up for a forgotten dose.
Do not stop taking Leukeran without your doctor’s advice.
If you have any further questions on the use of this medicine, ask your doctor or nurse.
Like all medicines, Leukeran can cause side effects, although not everybody gets them.
Talk to your doctor if you have any of the following side effects, which may also happen with this medicine:
Very Common (affects more than 1 in 10 people)
Common (affects less than 1 in 10 people)
Uncommon (affects less than 1 in 100 people)
Rare (affects less than 1 in 1,000 people)
Very rare (affects less than 1 in 10,000 people)
Not known (frequency cannot be estimated from the available data)
If you get any side effects, talk to your doctor or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via:
By reporting side effects you can help provide more information on the safety of this medicine.
The active substance is chlorambucil. Each Leukeran tablet contains 2 mg of chlorambucil.
The other ingredients are microcrystalline cellulose, anhydrous lactose, colloidal anhydrous silica, stearic acid, hypromellose, titanium dioxide (E171), synthetic yellow iron oxide (E172), synthetic red iron oxide (E172) and macrogol.
Leukeran tablets are brown, film-coated, round, biconvex tablets engraved ‘GX EG3’ on one side and ‘L’ on the other. Your Leukeran tablets are in bottles of 25 and 50 tablets.
Not all pack sizes may be marketed.
Marketing Authorisation holder:
For any Medical Information enquiries about this product, please contact:
Tel: 00353 1 630 8400
Tel: 00356 21497982