NEBILET PLUS 5 mg / 12.5 mg film-coated tablets
Nebivolol / Hydrochlorothiazide
1. What Nebilet Plus is and what it is used for
2. What you need to know before you take Nebilet Plus
3. How to take Nebilet Plus
4. Possible side effects
5. How to store Nebilet Plus
6. Contents of the pack and other information
Nebilet Plus contains nebivolol and hydrochlorothiazide as the active ingredients.
Nebilet Plus is a one-tablet combination of nebivolol and hydrochlorothiazide and is used for the treatment of raised blood pressure (hypertension). It is used instead of the two separate products for those patients who are already taking them together.
Talk to your doctor or pharmacist before taking Nebilet Plus.
Because of the lack of data on the use of the product in children and adolescents, Nebilet Plus is not recommended for use in them.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Always tell your doctor if you are using or receiving any of the following medicines in addition to Nebilet Plus:
Take care when drinking alcohol while you are taking Nebilet Plus, as you may feel faint or dizzy. If this happens to you, do not drink any alcohol, including wine, beer or alcopops.
You must tell your doctor if you are pregnant or if you think that you are. Usually, your doctor will advise you to take another medicine instead of Nebilet Plus, as Nebilet Plus is not recommended during pregnancy. This is because the active ingredient hydrochlorothiazide crosses the placenta. The use of Nebilet Plus during pregnancy may cause potentially harmful foetal and neonatal effects.
Tell your doctor if you are breast-feeding or about to start breast-feeding. Nebilet Plus is not recommended for mothers who are breast-feeding.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
This medicine may cause dizziness or fatigue. If affected, do not drive or operate machinery.
This product contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure.
Take 1 tablet a day with some water, preferably at the same time of day.
Nebilet Plus may be taken before, during or after a meal, but you can take it independently of meals.
Do not give Nebilet Plus to children or adolescents.
The score line is only there to help you break the tablet if you have difficulty swallowing it whole.
If you accidentally take an overdose of this medicine, tell your doctor or pharmacist immediately. The most frequent symptoms and signs of overdose are very slow heart beat (bradycardia), low blood pressure with possible fainting, breathlessness such as in asthma, acute heart failure, excessive urination with consequent dehydration, nausea and somnolence, muscle spasms, heart rhythm disturbances (especially if you are also taking digitalis or medicines for heart rhythm problems).
If you forget a dose of Nebilet Plus, but remember a little later on that you should have taken it, take that day’s dose as usual. However, if a long delay has occurred (e.g. several hours), so that the next due dose is near, skip the forgotten dose and take the next, scheduled, normal dose at the usual time. Do not take a double dose. Repeated skipping, however, should be avoided.
Always consult your doctor before stopping Nebilet Plus treatment.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The following side effects have been reported with nebivolol:
Common side effects (may affect up to 1 in 10 people):
Uncommon side effects (may affect up to 1 in 100 people):
Very rare side effects (may affect up to 1 in 10,000 people):
The following side effects have been reported only in some isolated cases:
The following side effects have been reported with hydrochlorothiazide:
Heart and circulation
Stomach and gut
Skin and hair
Eyes and ears
Joint and muscles
If you get any side effects talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via
By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
This medicinal product does not require any special storage condition.
Do not use this medicine after the expiry date which is stated on the box and on the blister pack after ‘EXP’. The expiry date refers to the last day of that month.
Do not throw away any medicine via wastewater or household waste.
Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
Nebilet Plus is available as almost pink, round, slightly biconvex film-coated tablets with “5/12.5” embossed on one side and a score line on the other side in packs of 7, 14, 28, 30, 56, 90 film-coated tablets.
Tablets are provided in blisters (PP/COC/PP/Aluminium blister).
(Not all pack sizes may be marketed)
Marketing Authorisation Holder
This medicinal product is authorised in the member states of the EEA under the following names
Austria: Nomexor plus HCT
Iceland: Nebilet Comp
Ireland: Nebilet Plus
Portugal: Hypoloc Plus
Spain: Silostar Plus
Sweden: Nebilet Comp
The Netherlands: Hyporetic
United Kingdom: Nebizide