| Xigduo 5 mg/850 mg and 5 mg/1,000 mg film coated tablets | - |  09/08/19 |  09/08/19 | Dapagliflozin propanediol monohydrate, Metformin Hydrochloride | AstraZeneca Pharmaceuticals (Ireland) DAC |
| Xofigo 1100 kBq/mL solution for injection | | 21/12/18 | 17/10/18 | radium-223 dichloride | Bayer Limited |
| Xolair 150mg solution for injection | - | 09/08/19 | 29/07/19 | Omalizumab | Novartis Ireland Limited |
| Xolair 75mg solution for injection | - | 09/08/19 | 29/07/19 | Omalizumab | Novartis Ireland Limited |
| Xomolix 2.5mg/ml solution for injection | - | 21/01/19 | 21/01/19 | Droperidol | Kyowa Kirin Ltd |
| Xtandi 40 mg soft capsules | - | 10/06/19 | 30/10/18 | enzalutamide | Astellas Pharma Co. Ltd |
| Xultophy 100 units/ml + 3.6 mg/ml solution for injection | | 22/07/19 | 22/07/19 | Insulin degludec, liraglutide | Novo Nordisk Limited |
| Xydalba 500 mg powder for concentrate for solution for infusion | | 24/01/19 | 24/01/19 | Dalbavancin hydrochloride | Correvio |
| Xylocaine 2% with Adrenaline | - | 11/06/18 | 21/09/17 | Adrenaline tartrate, lidocaine hydrochloride anhydrous | Aspen |
| Xylocaine Spray 10mg | - | 29/05/19 | 16/05/17 | Lidocaine | Aspen |
| Xyrem 500mg/ml oral solution | - | 22/03/19 | 22/03/19 | Sodium oxybate | UCB (Pharma) Ireland Limited |
| Xyzal 0.5mg/ml oral solution | - | 17/08/18 | 17/09/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Xyzal 5mg Tablets | - | 17/08/18 | 17/08/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Xyzal 5mg/ml Oral Drops, Solution | - | 17/08/18 | 17/08/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Yasmin 0.03 mg/3mg film-coated tablets | - | 19/12/18 | 19/12/18 | Drospirenone, Ethinylestradiol | Bayer Limited |
| Yasminelle | - | 19/12/18 | 19/12/18 | Drospirenone, ethinylestradiol betadex clathrate | Bayer Limited |
| Yaz 0.02mg / 3mg film coated tablets | - | 19/12/18 | 19/12/18 | Drospirenone, ethinylestradiol betadex clathrate | Bayer Limited |
| Yellox 0.9 mg/ml eye drops solution | - | 05/03/18 | 30/08/16 | Bromfenac sodium sesquihydrate | Bausch Health Ireland Ltd. |
| Yentreve | - | 23/08/19 | 23/08/19 | duloxetine hydrochloride | Eli Lilly and Company (Ireland) Limited |
| Yervoy 5mg per ml concentrate for solution for infusion | - | 22/08/19 | 22/08/19 | ipilimumab | Bristol-Myers Squibb Pharma EEIG |
| YESCARTA (axicabtagene ciloleucel) | | 05/06/19 | 05/06/19 | Axicabtagene Ciloleucel | Gilead Sciences Ltd |
| Yondelis 0.25 mg powder for concentrate for solution for infusion/Yondelis 1 mg powder for concentrate for solution for infusion | - | 23/07/18 | 23/07/18 | Trabectedin | Immedica (distributor) |
| Zaltrap 25mg/ml concentrate for solution for infusion | - | 16/07/18 | 12/08/19 | Aflibercept | SANOFI |
| Zanidip 10mg and 20mg Tablets | - | 11/08/17 | - | Lercanidipine Hydrochloride | Recordati Ireland Limited |
| Zanidip 10mg Tablets | - | - | 18/08/17 | Lercanidipine Hydrochloride | Recordati Ireland Limited |
