| Nytol One-A-Night 50 mg Tablets | - |  09/12/19 |  09/12/19 | Diphenhydramine Hydrochloride | Chefaro Ireland Ltd |
| Nyxoid 1.8 mg nasal spray | - | 03/07/19 | 03/07/19 | Naloxone Hydrochloride dihydrate | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OBIZUR 500 U powder and solvent for solution for injection | | 08/06/17 | 18/04/17 | | Shire Pharmaceuticals Limited |
| Occlusal | - | 27/03/19 | 22/03/19 | Salicylic Acid | Alliance Pharmaceuticals Ireland |
| OCREVUS 300 mg concentrate for solution for infusion | | 13/12/18 | 06/01/20 | Ocrelizumab | Roche Registration GmbH |
| Octaplex 1000 IU coagulation factor IX per vial, powder and solvent for solution for infusion | - | 17/07/18 | 15/08/18 | Human Prothrombin Complex | Octapharma Ltd |
| Octaplex 500 IU coagulation factor IX per vial, powder and solvent for solution for infusion | - | 17/07/18 | 15/08/18 | Human Prothrombin Complex | Octapharma Ltd |
| Octreotide 100 micrograms/1 ml Solution for Injection | - | 29/04/19 | 29/04/19 | octreotide acetate | Pfizer Healthcare Ireland |
| Octreotide 200 micrograms/ml Solution for Injection | - | 29/04/19 | 29/04/19 | octreotide acetate | Pfizer Healthcare Ireland |
| Octreotide 50 micrograms/1 ml Solution for Injection | - | 29/04/19 | 29/04/19 | octreotide acetate | Pfizer Healthcare Ireland |
| Octreotide 500 micrograms1 ml Solution for Injection | - | 29/04/19 | 29/04/19 | octreotide acetate | Pfizer Healthcare Ireland |
| Odefsey 200 mg/25 mg/25 mg film-coated tablets | | 29/07/19 | 29/07/19 | Emtricitabine, Rilpivirine Hydrochloride, Tenofovir alafenamide fumarate | Gilead Sciences Ltd |
| Odrik 1mg Hard Capsules | - | 12/04/19 | 28/03/19 | Trandolapril | Mylan IRE Healthcare Limited |
| Odrik 2mg Hard Capsules | - | 12/04/19 | 28/03/19 | Trandolapril | Mylan IRE Healthcare Limited |
| Ofev 100 mg soft capsules | - | 20/01/20 | 20/01/20 | Nintedanib esilate | Boehringer Ingelheim Limited |
| Ofev 150 mg soft capsules | - | 20/01/20 | 20/01/20 | Nintedanib esilate | Boehringer Ingelheim Limited |
| Ogivri 150 mg powder for concentrate for solution for infusion | - | 07/02/20 | 07/02/20 | Trastuzumab | Gerard Laboratories |
| Oilatum Cream | - | 07/11/16 | 07/11/16 | Light Liquid Paraffin, White Soft Paraffin | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Oilatum Emollient 63.4% w/w Bath Additive | - | 03/10/19 | 10/07/15 | Light Liquid Paraffin | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Oilatum Junior Emollient Bath Additive | - | 29/04/16 | 10/07/15 | Light Liquid Paraffin | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Oilatum Junior Flare-Up Bath Additive | - | 03/10/19 | 07/11/16 | Benzalkonium Chloride, Light Liquid Paraffin, Triclosan | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Oilatum Plus Bath Additive | - | 03/10/19 | 26/10/17 | Benzalkonium Chloride, Light Liquid Paraffin, Triclosan | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Oilatum Shower Gel 70% w/w Gel | - | 01/11/16 | 10/07/15 | Light Liquid Paraffin | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Olanzapine Mylan 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg & 20 mg film-coated tablets | - | 08/08/19 | 07/08/19 | Olanzapine | Gerard Laboratories |
| Olmesartan Amlodipine Mylan - 20mg/5mg, 40mg/10mg, 40mg/5mg | - | 29/08/19 | 29/08/19 | Amlodipine besilate, olmesartan medoxomil | Gerard Laboratories |
