| Xyrem 500mg/ml oral solution | - |  22/03/19 |  22/03/19 | Sodium oxybate | UCB (Pharma) Ireland Limited |
| Xyzal 0.5mg/ml oral solution | - | 17/08/18 | 17/09/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Xyzal 5mg Tablets | - | 17/08/18 | 17/08/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Xyzal 5mg/ml Oral Drops, Solution | - | 17/08/18 | 17/08/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Yasmin 0.03 mg/3mg film-coated tablets | - | 19/12/18 | 19/12/18 | Drospirenone, Ethinylestradiol | Bayer Limited |
| Yasminelle | - | 19/12/18 | 19/12/18 | Drospirenone, ethinylestradiol betadex clathrate | Bayer Limited |
| Yaz 0.02mg / 3mg film coated tablets | - | 19/12/18 | 19/12/18 | Drospirenone, ethinylestradiol betadex clathrate | Bayer Limited |
| Yellox 0.9 mg/ml eye drops solution | - | 05/03/18 | 30/08/16 | Bromfenac sodium sesquihydrate | Bausch Health Ireland Ltd. |
| Yentreve | - | 23/08/19 | 23/08/19 | duloxetine hydrochloride | Eli Lilly and Company (Ireland) Limited |
| Yervoy 5mg per ml concentrate for solution for infusion | - | 22/01/20 | 22/01/20 | ipilimumab | Bristol-Myers Squibb Pharma EEIG |
| YESCARTA (axicabtagene ciloleucel) | | 24/01/20 | 24/01/20 | Axicabtagene Ciloleucel | Gilead Sciences Ltd |
| Yondelis 0.25 mg powder for concentrate for solution for infusion/Yondelis 1 mg powder for concentrate for solution for infusion | - | 02/03/20 | 02/03/20 | Trabectedin | Immedica (distributor) |
| Zaltrap 25mg/ml concentrate for solution for infusion | - | 11/11/19 | 16/01/20 | Aflibercept | SANOFI |
| Zanidip 10mg and 20mg Tablets | - | 29/11/19 | - | Lercanidipine Hydrochloride | Recordati Ireland Limited |
| Zanidip 10mg Tablets | - | - | 29/11/19 | Lercanidipine Hydrochloride | Recordati Ireland Limited |
| Zanidip 20mg Tablets | - | - | 29/11/19 | Lercanidipine Hydrochloride | Recordati Ireland Limited |
| Zantac 75 (GSL) | - | 24/07/17 | 30/09/19 | Ranitidine Hydrochloride | Chefaro Ireland Ltd |
| Zantac 75 (P) | - | 04/10/19 | 04/10/19 | Ranitidine Hydrochloride | Chefaro Ireland Ltd |
| Zantac Effervescent Tablets 150mg | - | 11/09/18 | 11/09/18 | Ranitidine Hydrochloride | GlaxoSmithKline (Ireland) Ltd |
| Zantac Injection 25mg/ml | - | 18/12/19 | 18/12/19 | Ranitidine Hydrochloride | GlaxoSmithKline (Ireland) Ltd |
| Zantac Syrup | - | 05/12/19 | 05/12/19 | Ranitidine Hydrochloride | GlaxoSmithKline (Ireland) Ltd |
| Zantac Tablets 150mg | - | 03/03/20 | 03/03/20 | Ranitidine Hydrochloride | GlaxoSmithKline (Ireland) Ltd |
| Zantac Tablets 300mg | - | 03/03/20 | 24/03/20 | Ranitidine Hydrochloride | GlaxoSmithKline (Ireland) Ltd |
| Zavedos 5mg Powder for Solution for Injection | - | 12/10/18 | 12/10/18 | Idarubicin Hydrochloride | Pfizer Healthcare Ireland |
| Zavesca 100mg hard capsules | - | 24/02/20 | 24/02/20 | Miglustat | Actelion, a division of Janssen-Cilag International NV |
