| Xeplion 25 mg, 50 mg, 75 mg, 100 mg and 150 mg prolonged-release suspension for injection | - |  23/10/18 |  22/10/18 | Paliperidone palmitate | Janssen Sciences Ireland |
| Xermelo 250 mg film-coated tablets | | 20/11/19 | 21/11/19 | Telotristat ethyl | Ipsen Pharmaceuticals Ltd |
| XGEVA | - | 24/05/19 | 23/05/19 | Denosumab | Amgen Ltd |
| Xiapex 0.9 mg powder and solvent for solution for injection | - | 02/07/19 | 02/07/19 | Collagenase clostridium histolyticum | Swedish Orphan Biovitrum Ltd |
| Xigduo 5 mg/850 mg and 5 mg/1,000 mg film coated tablets | - | 25/10/19 | 25/10/19 | Dapagliflozin propanediol monohydrate, Metformin Hydrochloride | AstraZeneca Pharmaceuticals (Ireland) DAC |
| Xofigo 1100 kBq/mL solution for injection | | 21/12/18 | 17/10/18 | radium-223 dichloride | Bayer Limited |
| Xolair 150mg solution for injection | - | 09/08/19 | 29/07/19 | Omalizumab | Novartis Ireland Limited |
| Xolair 75mg solution for injection | - | 09/08/19 | 29/07/19 | Omalizumab | Novartis Ireland Limited |
| Xomolix 2.5mg/ml solution for injection | - | 21/01/19 | 21/01/19 | Droperidol | Kyowa Kirin Ltd |
| Xtandi 40 mg soft capsules | - | 10/06/19 | 30/10/18 | enzalutamide | Astellas Pharma Co. Ltd |
| Xultophy 100 units/ml + 3.6 mg/ml solution for injection | - | 04/10/19 | 04/10/19 | Insulin degludec, liraglutide | Novo Nordisk Limited |
| Xydalba 500 mg powder for concentrate for solution for infusion | | 24/01/19 | 24/01/19 | Dalbavancin hydrochloride | Correvio |
| Xylocaine 2% with Adrenaline | - | 11/06/18 | 21/09/17 | Adrenaline tartrate, lidocaine hydrochloride anhydrous | Aspen |
| Xylocaine Spray 10mg | - | 29/05/19 | 16/05/17 | Lidocaine | Aspen |
| Xyrem 500mg/ml oral solution | - | 22/03/19 | 22/03/19 | Sodium oxybate | UCB (Pharma) Ireland Limited |
| Xyzal 0.5mg/ml oral solution | - | 17/08/18 | 17/09/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Xyzal 5mg Tablets | - | 17/08/18 | 17/08/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Xyzal 5mg/ml Oral Drops, Solution | - | 17/08/18 | 17/08/18 | Levocetirizine dihydrochloride | UCB (Pharma) Ireland Limited |
| Yasmin 0.03 mg/3mg film-coated tablets | - | 19/12/18 | 19/12/18 | Drospirenone, Ethinylestradiol | Bayer Limited |
| Yasminelle | - | 19/12/18 | 19/12/18 | Drospirenone, ethinylestradiol betadex clathrate | Bayer Limited |
| Yaz 0.02mg / 3mg film coated tablets | - | 19/12/18 | 19/12/18 | Drospirenone, ethinylestradiol betadex clathrate | Bayer Limited |
| Yellox 0.9 mg/ml eye drops solution | - | 05/03/18 | 30/08/16 | Bromfenac sodium sesquihydrate | Bausch Health Ireland Ltd. |
| Yentreve | - | 23/08/19 | 23/08/19 | duloxetine hydrochloride | Eli Lilly and Company (Ireland) Limited |
| Yervoy 5mg per ml concentrate for solution for infusion | - | 08/10/19 | 08/10/19 | ipilimumab | Bristol-Myers Squibb Pharma EEIG |
| YESCARTA (axicabtagene ciloleucel) | | 05/06/19 | 05/06/19 | Axicabtagene Ciloleucel | Gilead Sciences Ltd |
