| Orkambi 200 mg/125 mg tablets and 100mg/125mg tablets | |  08/02/19 |  08/02/19 | Ivacaftor, Lumacaftor | Vertex Pharmaceuticals (Ireland) Limited |
| Oruvail 200mg Prolonged Release Capsules, Hard | - | 02/02/17 | 06/02/17 | Ketoprofen | SANOFI |
| Osmohale Inhalation Powder, Hard Capsule | - | 21/03/19 | 21/03/19 | Mannitol | Pharmaxis Europe Limited |
| Osteofos D3 | - | 04/05/17 | 04/05/17 | Calcium phosphate, Colecalciferol (Vitamin D3) | A. Menarini Pharmaceuticals Ireland Ltd |
| Otezla 10mg, 20mg, 30mg | - | 06/09/19 | 25/10/19 | Apremilast | Celgene Ltd |
| Otrivine Adult 0.1% w/v Nasal Drops, Solution | - | 18/06/19 | 03/10/16 | Xylometazoline Hydrochloride | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Otrivine Adult 0.1% w/v Nasal Spray, Solution | - | 18/06/19 | 03/10/16 | Xylometazoline Hydrochloride | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Otrivine Adult Measured Dose Sinusitus 0.1% w/v Nasal Spray, Solution | - | 18/06/19 | 03/10/16 | Xylometazoline Hydrochloride | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Otrivine Adult Mucus Relief Menthol, 0.1% w/v Nasal Spray | - | 08/08/19 | 04/10/16 | Xylometazoline Hydrochloride | GlaxoSmithKline Consumer Healthcare (Ireland) Ltd |
| Ovestin 1mg per gram Vaginal cream | - | 21/05/18 | 08/10/19 | Estriol | Aspen |
| Ovitrelle 250 micrograms/0.5 ml pre-filled pen | - | 01/11/18 | 26/10/18 | Choriogonadotropin alfa | Merck |
| Ovranette 150micrograms/30micrograms Coated Tablets | - | 04/11/19 | 31/10/19 | Ethinylestradiol, Levonorgestrel | Pfizer Healthcare Ireland |
| Ovreena 30 micrograms/150 micrograms coated tablets | - | 20/05/19 | 18/05/19 | Ethinylestradiol, Levonorgestrel | Consilient Health Ltd |
| Oxis Turbohaler 12mcg | - | 17/01/19 | 17/01/19 | Formoterol fumarate dihydrate | AstraZeneca Pharmaceuticals (Ireland) DAC |
| Oxis Turbohaler 6mcg | - | 17/01/19 | 17/01/19 | Formoterol fumarate dihydrate | AstraZeneca Pharmaceuticals (Ireland) DAC |
| OxyContin prolonged release tablets | - | 03/04/19 | 03/04/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OxyNorm 10 mg/ml solution for Injection or Infusion | - | 03/04/19 | 03/04/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OxyNorm 50 mg/ml, solution for injection or infusion | - | 03/04/19 | 28/05/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OxyNorm Capsules | - | 03/04/19 | 03/04/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OxyNorm Concentrate | - | 03/04/19 | 03/04/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OxyNorm Dispersa 5, 10, 20 mg orodispersible tablets | - | 03/04/19 | 28/05/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| OxyNorm liquid 1 mg/ml oral solution | - | 03/04/19 | 03/04/19 | Oxycodone Hydrochloride | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| Ozempic 0.25 mg solution for injection in pre-filled pen | | 21/08/18 | 15/11/18 | Semaglutide | Novo Nordisk Limited |
| Ozempic 0.5 mg solution for injection in pre-filled pen | | 21/08/18 | 15/11/18 | Semaglutide | Novo Nordisk Limited |
| Ozempic 1 mg solution for injection in pre-filled pen | | 21/08/18 | 15/11/18 | Semaglutide | Novo Nordisk Limited |
