| Seretide Diskus | - |  06/04/18 |  05/11/18 | Fluticasone Propionate, Salmeterol Xinafoate | GlaxoSmithKline (Ireland) Ltd |
| Seretide Evohaler | - | 06/04/18 | 04/06/19 | Fluticasone Propionate, Salmeterol Xinafoate | GlaxoSmithKline (Ireland) Ltd |
| Serevent Diskus | - | 27/07/15 | 21/07/15 | Salmeterol Xinafoate | GlaxoSmithKline (Ireland) Ltd |
| Serevent Evohaler | - | 20/07/15 | 21/07/15 | Salmeterol Xinafoate | GlaxoSmithKline (Ireland) Ltd |
| Seroquel Tablets 25mg, 100mg, 200mg and 300mg | - | 09/05/19 | 23/01/19 | Quetiapine fumarate | AstraZeneca Pharmaceuticals (Ireland) DAC |
| Seroquel XR 50mg, 150mg, 200mg, 300mg, 400mg prolonged-release tablets | - | 09/05/19 | 23/01/19 | Quetiapine fumarate | AstraZeneca Pharmaceuticals (Ireland) DAC |
| Seroxat Liquid | - | 16/09/19 | 16/09/19 | Paroxetine hydrochloride hemihydrate | GlaxoSmithKline (Ireland) Ltd |
| Seroxat Tablets | - | 16/09/19 | 16/09/19 | Paroxetine hydrochloride hemihydrate | GlaxoSmithKline (Ireland) Ltd |
| Sevelamer Carbonate 800mg film-coated tablets | - | 14/10/19 | 14/10/19 | Sevelamer carbonate | Gerard Laboratories |
| Sevoflurane Baxter, 100%, inhalation vapour, liquid | - | - | 18/03/19 | Sevoflurane | Baxter Holding B.V. |
| Sevorane | - | 21/02/19 | 21/02/19 | Sevoflurane | AbbVie Limited |
| SEVREDOL Tablets | - | 10/04/19 | 18/06/19 | Morphine sulfate | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| Sialanar 320 micrograms/ml Glycopyrronium (400 micrograms/ml Glycopyrronium Bromide) Oral Solution | - | 09/10/19 | 09/10/19 | Glycopyrronium bromide, Glycopyrrolate | Proveca Limited |
| Sibelium 5 mg tablets | - | 04/04/19 | 04/04/19 | Flunarizine dihydrochloride | Janssen Sciences Ireland |
| Siklos 100 mg film-coated tablets | - | 13/09/19 | 16/07/19 | Hydroxycarbamide | ADDMEDICA |
| Sildenafil Mylan 25 mg, 50 mg & 100 mg film-coated tablets | - | 21/06/18 | 14/06/19 | sildenafil citrate | Gerard Laboratories |
| Sildenafil Pfizer 25mg, 50mg, 100mg film–coated tablets | - | 07/01/16 | 18/01/19 | sildenafil citrate | Pfizer Healthcare Ireland |
| Silkis Ointment | - | 14/07/17 | 24/07/19 | Calcitriol | Galderma International S.A.S. c/o Galderma (U.K) Ltd. |
| SIMBRINZA 10 mg/mL + 2 mg/mL eye drops, suspension | - | 29/08/19 | 03/10/19 | brimonidine tartrate, Brinzolamide | Novartis Ireland Limited |
| Simponi 100 mg solution for injection, pre filled pen | - | 17/06/19 | 13/06/19 | Golimumab | MSD Ireland (Human Health) Limited |
| Simponi 50 mg solution for injection, pre filled pen | - | 17/06/19 | 13/06/19 | Golimumab | MSD Ireland (Human Health) Limited |
| Simponi 50 mg solution for injection, pre filled syringe | - | 13/06/19 | 13/06/19 | Golimumab | MSD Ireland (Human Health) Limited |
| Simulect 20mg powder and solvent for solution for injection or infusion | - | 23/01/19 | 09/04/19 | Basiliximab | Novartis Ireland Limited |
| Simvastatin 10mg 20mg & 40mg Film-coated Tablets | - | 08/08/19 | 08/08/19 | Simvastatin | Gerard Laboratories |
| Sinemet 10mg/100mg, Plus 25mg/100mg & 25mg/250mg Tablets | - | 21/05/19 | 21/05/19 | Carbidopa, Levodopa | MSD Ireland (Human Health) Limited |
