| Sevorane | - |  21/02/19 |  21/02/19 | Sevoflurane | AbbVie Limited |
| SEVREDOL Tablets | - | 10/04/19 | 18/06/19 | Morphine sulfate | Mundipharma Pharmaceuticals Limited - Formerly Napp Laboratories |
| Sialanar 320 micrograms/ml Glycopyrronium (400 micrograms/ml Glycopyrronium Bromide) Oral Solution | - | 12/04/19 | 12/04/19 | Glycopyrronium bromide, Glycopyrrolate | Proveca Limited |
| Sibelium 5 mg tablets | - | 04/04/19 | 04/04/19 | Flunarizine dihydrochloride | Janssen Sciences Ireland |
| Siklos 100 mg film-coated tablets | - | 13/09/19 | 16/07/19 | Hydroxycarbamide | ADDMEDICA |
| Sildenafil Mylan 25 mg, 50 mg & 100 mg film-coated tablets | - | 21/06/18 | 14/06/19 | sildenafil citrate | Gerard Laboratories |
| Sildenafil Pfizer 25mg, 50mg, 100mg film–coated tablets | - | 07/01/16 | 18/01/19 | sildenafil citrate | Pfizer Healthcare Ireland |
| Silkis Ointment | - | 14/07/17 | 24/07/19 | Calcitriol | Galderma (U.K) Ltd |
| SIMBRINZA 10 mg/mL + 2 mg/mL eye drops, suspension | - | 29/08/19 | 08/04/19 | brimonidine tartrate, Brinzolamide | Novartis Ireland Limited |
| Simponi 100 mg solution for injection, pre filled pen | - | 17/06/19 | 13/06/19 | Golimumab | MSD Ireland (Human Health) Limited |
| Simponi 50 mg solution for injection, pre filled pen | - | 17/06/19 | 13/06/19 | Golimumab | MSD Ireland (Human Health) Limited |
| Simponi 50 mg solution for injection, pre filled syringe | - | 13/06/19 | 13/06/19 | Golimumab | MSD Ireland (Human Health) Limited |
| Simulect 20mg powder and solvent for solution for injection or infusion | - | 23/01/19 | 09/04/19 | Basiliximab | Novartis Ireland Limited |
| Simvastatin 10mg 20mg & 40mg Film-coated Tablets | - | 08/08/19 | 08/08/19 | Simvastatin | Gerard Laboratories |
| Sinemet 10mg/100mg, Plus 25mg/100mg & 25mg/250mg Tablets | - | 21/05/19 | 21/05/19 | Carbidopa, Levodopa | MSD Ireland (Human Health) Limited |
| Sinemet 12.5mg/50mg Tablets | - | 21/02/19 | 21/05/19 | Carbidopa, Levodopa | MSD Ireland (Human Health) Limited |
| SINEMET CR 50mg/200mg Prolonged-release Tablets | - | 15/07/19 | 28/08/18 | Carbidopa, Levodopa | MSD Ireland (Human Health) Limited |
| Singulair 10mg Film-coated Tablets | - | 10/08/18 | 18/06/19 | Montelukast Sodium | MSD Ireland (Human Health) Limited |
| Singulair Paediatric 4mg Oral Granules | - | 10/08/18 | 18/06/19 | Montelukast Sodium | MSD Ireland (Human Health) Limited |
| Singulair Paediatric 5mg Chewable Tablets | - | 10/08/18 | 20/06/19 | Montelukast Sodium | MSD Ireland (Human Health) Limited |
| Sirdupla 25 microgram/125 microgram, 25 microgram/250 microgram per metered dose pressurised inhalation, suspension | - | 26/02/19 | 08/08/19 | Fluticasone Propionate, Salmeterol Xinafoate | Gerard Laboratories |
| SIRTURO 100 mg tablets | | 23/10/18 | 27/03/19 | Bedaquiline fumarate | Janssen Sciences Ireland |
| Sivextro 200 mg film-coated tablets | | 22/08/18 | 21/08/18 | Tedizolid phosphate | MSD Ireland (Human Health) Limited |
| Sivextro 200 mg powder for concentrate for solution for infusion | | 22/08/18 | 21/08/18 | Tedizolid phosphate | MSD Ireland (Human Health) Limited |
| Skilarence 30 mg gastro-resistant tablets | - | 30/01/19 | - | Dimethyl fumarate | Almirall Limited |
